Preheat your oven to 400°F (200°C). Line a baking sheet with parchment paper or foil and lightly grease it.
Season the chicken with salt and pepper. Dredge each piece in flour, dip into the beaten eggs, then coat in panko breadcrumbs. Place the coated pieces on the prepared baking sheet.
Lightly spray or drizzle the chicken with oil. Bake for 20–25 minutes, flipping halfway through, until golden and cooked through.
While the chicken bakes, combine orange juice, soy sauce, vinegar, honey, orange zest, garlic, ginger, and red pepper flakes in a saucepan. Bring to a simmer over medium heat. Stir in the cornstarch slurry and cook until thickened, about 2–3 minutes.
Once the chicken is baked, transfer it to a large bowl. Pour the orange sauce over the chicken and toss until evenly coated. Serve immediately over rice or noodles.